Drug interactions
Indacaterol + Ziprasidone
Severity: Major
Indacaterol and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is among the antipsychotics with a clear QT-prolonging effect, and indacaterol may add to proarrhythmic risk through beta2 stimulation and lower potassium. Together they may increase the likelihood of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Indacaterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization: ziprasidone blocks hERG potassium channels while beta2-agonism promotes tachycardia and hypokalemia.
What to do
Avoid the combination when possible in patients with QT risk factors, or use an alternative bronchodilator. If co-administered, obtain a baseline ECG, maintain normal potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Indacaterol with Ziprasidone?
MediHelp rates the interaction as major. Indacaterol and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone is among the antipsychotics with a clear QT-prolonging effect, and indacaterol may add to proarrhythmic risk through beta2 stimulation and lower potassium. Together they may increase the likelihood of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Indacaterol and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible in patients with QT risk factors, or use an alternative bronchodilator. If co-administered, obtain a baseline ECG, maintain normal potassium and magnesium, and monitor the QTc.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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