Drug interactions
Indacaterol-glycopyrronium + Ipratropium
Severity: Moderate
Indacaterol-glycopyrronium and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium and ipratropium are both antimuscarinic bronchodilators, so using them together duplicates therapy. This increases anticholinergic adverse effects such as dry mouth, urinary retention, constipation and raised intraocular pressure.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ipratropium belongs to Respiratory.
Why it happens
Duplicate muscarinic receptor antagonism producing additive anticholinergic effects.
What to do
Avoid routine concurrent use of two long- or short-acting antimuscarinics; stop ipratropium when maintenance glycopyrronium is established. Monitor for urinary retention and narrow-angle glaucoma symptoms if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ipratropium?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium and ipratropium are both antimuscarinic bronchodilators, so using them together duplicates therapy. This increases anticholinergic adverse effects such as dry mouth, urinary retention, constipation and raised intraocular pressure.
How serious is the interaction between Indacaterol-glycopyrronium and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two long- or short-acting antimuscarinics; stop ipratropium when maintenance glycopyrronium is established. Monitor for urinary retention and narrow-angle glaucoma symptoms if combined.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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