Drug interactions
Indacaterol-glycopyrronium + Itraconazole
Severity: Major
Indacaterol-glycopyrronium and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and P-glycoprotein, which can raise indacaterol exposure, and both drugs can affect QT interval. This may lead to tachycardia, tremor, hypokalemia and arrhythmias.
What this interaction means in plain words
Indacaterol-glycopyrronium and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-gp by itraconazole increases indacaterol levels, combined with additive QT-prolonging potential.
What to do
Monitor heart rate, ECG and potassium, and watch for beta-agonist adverse effects. Consider an alternative antifungal or bronchodilator if symptoms or QT prolongation occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Itraconazole?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole strongly inhibits CYP3A4 and P-glycoprotein, which can raise indacaterol exposure, and both drugs can affect QT interval. This may lead to tachycardia, tremor, hypokalemia and arrhythmias.
How serious is the interaction between Indacaterol-glycopyrronium and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, and watch for beta-agonist adverse effects. Consider an alternative antifungal or bronchodilator if symptoms or QT prolongation occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
