Drug interactions
Indacaterol-glycopyrronium + Macimorelin
Severity: Moderate
Indacaterol-glycopyrronium and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in QT interval and should not be given with other QT-prolonging drugs. Indacaterol, a beta-agonist, may contribute to repolarization risk. The single-dose diagnostic use limits exposure, but torsades is a concern in susceptible patients.
What this interaction means in plain words
Indacaterol-glycopyrronium and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Where possible, withhold the inhaled combination for an appropriate period before the macimorelin test per clinical judgment. Review ECG and electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Macimorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Macimorelin
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Macimorelin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in QT interval and should not be given with other QT-prolonging drugs. Indacaterol, a beta-agonist, may contribute to repolarization risk. The single-dose diagnostic use limits exposure, but torsades is a concern in susceptible patients.
How serious is the interaction between Indacaterol-glycopyrronium and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, withhold the inhaled combination for an appropriate period before the macimorelin test per clinical judgment. Review ECG and electrolytes in patients with cardiac risk factors.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
