Drug interactions
Indacaterol-glycopyrronium + Mefloquine
Severity: Moderate
Indacaterol-glycopyrronium and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can alter cardiac conduction and prolong the QT interval, and beta-2 agonists may add to this effect and lower potassium. This may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation with beta-agonist-related hypokalemia.
What to do
Check ECG and electrolytes when risk factors exist. Choose a non-QT-prolonging antimalarial if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Mefloquine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can alter cardiac conduction and prolong the QT interval, and beta-2 agonists may add to this effect and lower potassium. This may increase the risk of ventricular arrhythmia.
How serious is the interaction between Indacaterol-glycopyrronium and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes when risk factors exist. Choose a non-QT-prolonging antimalarial if feasible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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