Drug interactions
Indacaterol-glycopyrronium + Oxaliplatin
Severity: Moderate
Indacaterol-glycopyrronium and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and electrolyte disturbances, and indacaterol may add to QT effects. The combination could raise arrhythmia risk in patients with additional risk factors.
What this interaction means in plain words
Indacaterol-glycopyrronium and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Oxaliplatin belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization; oxaliplatin-related hypokalemia and hypomagnesemia may amplify the effect.
What to do
Monitor ECG and correct potassium and magnesium before and during oxaliplatin cycles in patients using indacaterol. Use extra vigilance in those with heart disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Oxaliplatin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and electrolyte disturbances, and indacaterol may add to QT effects. The combination could raise arrhythmia risk in patients with additional risk factors.
How serious is the interaction between Indacaterol-glycopyrronium and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during oxaliplatin cycles in patients using indacaterol. Use extra vigilance in those with heart disease or other QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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