Drug interactions
Indacaterol-glycopyrronium + Paliperidone
Severity: Moderate
Indacaterol-glycopyrronium and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone prolongs the QT interval and has mild anticholinergic activity, while indacaterol may add to QT effects and lower potassium. Glycopyrronium adds to antimuscarinic effects, so the combination can raise arrhythmia and anticholinergic adverse effect risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Check ECG and electrolytes in patients with cardiac risk factors. Monitor for anticholinergic effects and tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Paliperidone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone prolongs the QT interval and has mild anticholinergic activity, while indacaterol may add to QT effects and lower potassium. Glycopyrronium adds to antimuscarinic effects, so the combination can raise arrhythmia and anticholinergic adverse effect risk.
How serious is the interaction between Indacaterol-glycopyrronium and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors. Monitor for anticholinergic effects and tachycardia.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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