Drug interactions
Indacaterol-glycopyrronium + Perphenazine
Severity: Moderate
Indacaterol-glycopyrronium and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic activity and can prolong the QT interval. With inhaled glycopyrronium and indacaterol, anticholinergic effects and arrhythmia risk may be increased.
What this interaction means in plain words
Indacaterol-glycopyrronium and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Perphenazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has anticholinergic activity and can prolong the QT interval. With inhaled glycopyrronium and indacaterol, anticholinergic effects and arrhythmia risk may be increased.
How serious is the interaction between Indacaterol-glycopyrronium and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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