Drug interactions
Indacaterol-glycopyrronium + Ribociclib
Severity: Major
Indacaterol-glycopyrronium and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes concentration-dependent QT prolongation, and indacaterol may add to cardiac repolarisation effects and lower potassium. The combination may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia.
What to do
Check ECG and electrolytes at baseline and during treatment, and correct abnormalities. Prefer an alternative bronchodilator if QT prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ribociclib?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes concentration-dependent QT prolongation, and indacaterol may add to cardiac repolarisation effects and lower potassium. The combination may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Indacaterol-glycopyrronium and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during treatment, and correct abnormalities. Prefer an alternative bronchodilator if QT prolongation develops.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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