Drug interactions
Indacaterol-glycopyrronium + Tacrolimus
Severity: Moderate
Indacaterol-glycopyrronium and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and cause hypokalemia or hypomagnesemia, and indacaterol may add to these effects. The clinical risk with inhaled indacaterol is likely small but is relevant in patients with other cardiac risk factors.
What this interaction means in plain words
Indacaterol-glycopyrronium and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation and electrolyte disturbances.
What to do
Monitor potassium and magnesium and obtain an ECG in patients with cardiac risk factors or symptoms such as palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Tacrolimus?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and cause hypokalemia or hypomagnesemia, and indacaterol may add to these effects. The clinical risk with inhaled indacaterol is likely small but is relevant in patients with other cardiac risk factors.
How serious is the interaction between Indacaterol-glycopyrronium and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and obtain an ECG in patients with cardiac risk factors or symptoms such as palpitations.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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