Drug interactions
Indacaterol-glycopyrronium + Vorinostat
Severity: Moderate
Indacaterol-glycopyrronium and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation and electrolyte disturbances, and indacaterol can contribute to hypokalemia and arrhythmias. The combination may increase risk of ventricular arrhythmia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization and potential for electrolyte disturbance.
What to do
Check baseline ECG, potassium, magnesium and calcium and monitor periodically. Correct abnormalities before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Vorinostat?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation and electrolyte disturbances, and indacaterol can contribute to hypokalemia and arrhythmias. The combination may increase risk of ventricular arrhythmia.
How serious is the interaction between Indacaterol-glycopyrronium and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium, magnesium and calcium and monitor periodically. Correct abnormalities before and during therapy.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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