Drug interactions
Indomethacin + Lacosamide
Severity: Minor
Indomethacin and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin is not a strong CYP2C9 inhibitor, and lacosamide is metabolized by several CYP enzymes, so a meaningful pharmacokinetic interaction is unlikely. No clinically significant effect is established.
What this interaction means in plain words
Indomethacin and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Lacosamide belongs to Central Nervous System.
Why it happens
Theoretical weak CYP2C9 inhibition only; no established mechanism.
What to do
No dose change is needed; monitor for lacosamide adverse effects such as dizziness or PR interval prolongation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Indomethacin with Lacosamide?
MediHelp rates the interaction as minor. Indomethacin and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin is not a strong CYP2C9 inhibitor, and lacosamide is metabolized by several CYP enzymes, so a meaningful pharmacokinetic interaction is unlikely. No clinically significant effect is established.
How serious is the interaction between Indomethacin and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for lacosamide adverse effects such as dizziness or PR interval prolongation as usual.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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