Drug interactions
Indomethacin + Methylprednisolone
Severity: Moderate
Indomethacin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a systemic corticosteroid with an NSAID raises the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with prolonged use, or with higher doses.
What this interaction means in plain words
Indomethacin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Methylprednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury: NSAID-related prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time, and consider adding a proton pump inhibitor in at-risk patients. Watch for dyspepsia, melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Methylprednisolone?
MediHelp rates the interaction as moderate. Indomethacin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a systemic corticosteroid with an NSAID raises the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with prolonged use, or with higher doses.
How serious is the interaction between Indomethacin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, and consider adding a proton pump inhibitor in at-risk patients. Watch for dyspepsia, melena or anemia.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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