Drug interactions
Indomethacin + Nitazoxanide
Severity: Minor
Indomethacin and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite tizoxanide is highly protein bound, so it could theoretically displace other highly bound drugs such as indomethacin. The effect on free drug levels is expected to be small given short courses of nitazoxanide.
What this interaction means in plain words
Indomethacin and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No routine adjustment is needed; observe for increased NSAID adverse effects during the nitazoxanide course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Indomethacin with Nitazoxanide?
MediHelp rates the interaction as minor. Indomethacin and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite tizoxanide is highly protein bound, so it could theoretically displace other highly bound drugs such as indomethacin. The effect on free drug levels is expected to be small given short courses of nitazoxanide.
How serious is the interaction between Indomethacin and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; observe for increased NSAID adverse effects during the nitazoxanide course.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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