Drug interactions
Indomethacin + Paromomycin
Severity: Minor
Indomethacin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In preterm infants indomethacin lowers renal perfusion and may raise levels of renally cleared aminoglycosides. Oral paromomycin is minimally absorbed, so significant exposure is unlikely unless the gut is damaged or kidney function is poor.
What this interaction means in plain words
Indomethacin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
Indomethacin reduces renal blood flow and glomerular filtration, decreasing aminoglycoside elimination.
What to do
No routine action is required. In neonates or patients with renal impairment or inflamed bowel, monitor renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Indomethacin with Paromomycin?
MediHelp rates the interaction as minor. Indomethacin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. In preterm infants indomethacin lowers renal perfusion and may raise levels of renally cleared aminoglycosides. Oral paromomycin is minimally absorbed, so significant exposure is unlikely unless the gut is damaged or kidney function is poor.
How serious is the interaction between Indomethacin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. In neonates or patients with renal impairment or inflamed bowel, monitor renal function.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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