Drug interactions
Indomethacin + Pretomanid
Severity: Minor
Indomethacin and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, and indomethacin is an OAT3 substrate, so its renal clearance could be reduced. The clinical significance is not established.
What this interaction means in plain words
Indomethacin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of indomethacin by pretomanid, shown in vitro.
What to do
Monitor for increased indomethacin adverse effects such as GI upset or renal changes and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Indomethacin with Pretomanid?
MediHelp rates the interaction as minor. Indomethacin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, and indomethacin is an OAT3 substrate, so its renal clearance could be reduced. The clinical significance is not established.
How serious is the interaction between Indomethacin and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased indomethacin adverse effects such as GI upset or renal changes and reduce the dose if they occur.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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