Drug interactions
Indomethacin + Sotalol
Severity: Moderate
Indomethacin and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may reduce the blood pressure lowering effect of sotalol, particularly with prolonged use. NSAID-related renal impairment can also reduce sotalol elimination and raise proarrhythmic risk.
What this interaction means in plain words
Indomethacin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID prostaglandin inhibition causes sodium and fluid retention and may reduce renal function, opposing beta-blockade and impairing renal sotalol clearance.
What to do
Monitor blood pressure, renal function and QT interval when indomethacin is given for more than a few days. Adjust sotalol dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Indomethacin with Sotalol?
MediHelp rates the interaction as moderate. Indomethacin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may reduce the blood pressure lowering effect of sotalol, particularly with prolonged use. NSAID-related renal impairment can also reduce sotalol elimination and raise proarrhythmic risk.
How serious is the interaction between Indomethacin and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and QT interval when indomethacin is given for more than a few days. Adjust sotalol dose if renal function declines.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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