Drug interactions
Indomethacin + Travoprost
Severity: Minor
Indomethacin and Travoprost: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic indomethacin could theoretically alter the intraocular pressure lowering effect of travoprost, because ocular prostaglandin analogues depend partly on prostaglandin-mediated outflow. Reports are inconsistent and no reliable clinically important effect is established.
What this interaction means in plain words
Indomethacin and Travoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Travoprost belongs to Miscellaneous.
Why it happens
Prostaglandin synthesis inhibition by indomethacin may modify the uveoscleral outflow effect of the prostaglandin analogue, but the mechanism is not firmly established.
What to do
No routine change is needed; check intraocular pressure at usual follow-up visits if indomethacin is started or stopped in a glaucoma patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Travoprost
- Bimatoprost + Travoprost Moderate
- Latanoprostene bunod + Travoprost Moderate
- Latanoprost + Travoprost Moderate
- Tafluprost + Travoprost Moderate
- Celecoxib + Travoprost Minor
- Diclofenac + Travoprost Minor
Frequently asked questions
Can I take Indomethacin with Travoprost?
MediHelp rates the interaction as minor. Indomethacin and Travoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic indomethacin could theoretically alter the intraocular pressure lowering effect of travoprost, because ocular prostaglandin analogues depend partly on prostaglandin-mediated outflow. Reports are inconsistent and no reliable clinically important effect is established.
How serious is the interaction between Indomethacin and Travoprost?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check intraocular pressure at usual follow-up visits if indomethacin is started or stopped in a glaucoma patient.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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