Drug interactions
Indomethacin + Vadadustat
Severity: Moderate
Indomethacin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3, a transporter involved in renal elimination of indomethacin, and may raise indomethacin exposure. This may increase NSAID-related adverse effects such as gastrointestinal and renal toxicity.
What this interaction means in plain words
Indomethacin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT3 by vadadustat reduces tubular secretion of indomethacin.
What to do
Monitor for NSAID adverse effects and consider reducing the indomethacin dose; check renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Indomethacin with Vadadustat?
MediHelp rates the interaction as moderate. Indomethacin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits OAT3, a transporter involved in renal elimination of indomethacin, and may raise indomethacin exposure. This may increase NSAID-related adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Indomethacin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects and consider reducing the indomethacin dose; check renal function in at-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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