Drug interactions
Infigratinib + Ranitidine
Severity: Moderate
Infigratinib and Ranitidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib solubility is pH-dependent, and acid-reducing drugs can lower its absorption, risking reduced anticancer efficacy.
What this interaction means in plain words
Infigratinib and Ranitidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ranitidine increases gastric pH, reducing the dissolution and absorption of infigratinib.
What to do
If unavoidable, take infigratinib 2 hours before or 10 hours after ranitidine; avoid proton pump inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranitidine
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Sparsentan Moderate
- Ranitidine + Trilaciclib Moderate
- Dofetilide + Ranitidine Minor
- Lonafarnib + Ranitidine Minor
Frequently asked questions
Can I take Infigratinib with Ranitidine?
MediHelp rates the interaction as moderate. Infigratinib and Ranitidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib solubility is pH-dependent, and acid-reducing drugs can lower its absorption, risking reduced anticancer efficacy.
How serious is the interaction between Infigratinib and Ranitidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, take infigratinib 2 hours before or 10 hours after ranitidine; avoid proton pump inhibitors.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Levoketoconazole, Sotorasib, Sparsentan. The full list is on the Ranitidine page.
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