Drug interactions
Ranitidine + Trilaciclib
Severity: Moderate
Ranitidine and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which contribute to renal secretion of ranitidine. Ranitidine concentrations may rise modestly.
What this interaction means in plain words
Ranitidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranitidine belongs to Gastrointestinal Tract; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2 and MATE-mediated tubular secretion of ranitidine, increasing its exposure.
What to do
Monitor for ranitidine adverse effects or use an alternative acid suppressant on trilaciclib treatment days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Sparsentan Moderate
- Dofetilide + Ranitidine Minor
- Lonafarnib + Ranitidine Minor
Other interactions of Trilaciclib
Frequently asked questions
Can I take Ranitidine with Trilaciclib?
MediHelp rates the interaction as moderate. Ranitidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which contribute to renal secretion of ranitidine. Ranitidine concentrations may rise modestly.
How serious is the interaction between Ranitidine and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ranitidine adverse effects or use an alternative acid suppressant on trilaciclib treatment days.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Infigratinib, Levoketoconazole, Sotorasib. The full list is on the Ranitidine page.
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