Drug interactions
Lonafarnib + Ranitidine
Severity: Minor
Lonafarnib and Ranitidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranitidine is not a meaningful CYP3A4 inhibitor, so a pharmacokinetic effect on lonafarnib is unlikely. The legacy concern appears to be class-based and not supported by known pharmacology.
What this interaction means in plain words
Lonafarnib and Ranitidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Ranitidine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; ranitidine does not significantly inhibit CYP3A4.
What to do
No adjustment is needed; monitor for lonafarnib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Sparsentan Moderate
- Ranitidine + Trilaciclib Moderate
- Dofetilide + Ranitidine Minor
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ranitidine?
MediHelp rates the interaction as minor. Lonafarnib and Ranitidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranitidine is not a meaningful CYP3A4 inhibitor, so a pharmacokinetic effect on lonafarnib is unlikely. The legacy concern appears to be class-based and not supported by known pharmacology.
How serious is the interaction between Lonafarnib and Ranitidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for lonafarnib adverse effects as usual.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Infigratinib, Levoketoconazole, Sotorasib. The full list is on the Ranitidine page.
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