Drug interactions
Dofetilide + Ranitidine
Severity: Minor
Dofetilide and Ranitidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranitidine has little or no effect on dofetilide exposure and is listed in the label as an acceptable alternative to cimetidine. Clinically significant QT effects from this pairing are not expected.
What this interaction means in plain words
Dofetilide and Ranitidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dofetilide belongs to Cardiovascular; Ranitidine belongs to Gastrointestinal Tract.
Why it happens
No meaningful inhibition of dofetilide renal secretion or metabolism at usual doses.
What to do
No dose adjustment is needed. Maintain standard dofetilide monitoring of QTc and creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Sparsentan Moderate
- Ranitidine + Trilaciclib Moderate
- Lonafarnib + Ranitidine Minor
Frequently asked questions
Can I take Dofetilide with Ranitidine?
MediHelp rates the interaction as minor. Dofetilide and Ranitidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranitidine has little or no effect on dofetilide exposure and is listed in the label as an acceptable alternative to cimetidine. Clinically significant QT effects from this pairing are not expected.
How serious is the interaction between Dofetilide and Ranitidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Maintain standard dofetilide monitoring of QTc and creatinine clearance.
What other medicines interact with Dofetilide?
MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.
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