Drug interactions
Levoketoconazole + Ranitidine
Severity: Moderate
Levoketoconazole and Ranitidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole needs gastric acid for dissolution, so acid suppression can reduce its absorption and its cortisol-lowering effect in Cushing syndrome.
What this interaction means in plain words
Levoketoconazole and Ranitidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Ranitidine belongs to Gastrointestinal Tract.
Why it happens
Ranitidine raises gastric pH, reducing dissolution and absorption of levoketoconazole.
What to do
Avoid concurrent acid suppressants where possible; if needed, give short-acting antacids at least 2 hours after levoketoconazole and monitor cortisol control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levoketoconazole and Ranitidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Sparsentan Moderate
- Ranitidine + Trilaciclib Moderate
- Dofetilide + Ranitidine Minor
- Lonafarnib + Ranitidine Minor
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Ranitidine?
MediHelp rates the interaction as moderate. Levoketoconazole and Ranitidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole needs gastric acid for dissolution, so acid suppression can reduce its absorption and its cortisol-lowering effect in Cushing syndrome.
How serious is the interaction between Levoketoconazole and Ranitidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent acid suppressants where possible; if needed, give short-acting antacids at least 2 hours after levoketoconazole and monitor cortisol control.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Infigratinib, Sotorasib, Sparsentan. The full list is on the Ranitidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
