Drug interactions
Ranitidine + Sparsentan
Severity: Moderate
Ranitidine and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan absorption may fall when gastric pH rises, which could weaken its antiproteinuric effect.
What this interaction means in plain words
Ranitidine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranitidine belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Ranitidine raises gastric pH, which may reduce sparsentan dissolution and absorption.
What to do
Monitor proteinuria and blood pressure response; consider separating dosing or choosing an alternative to the H2 blocker.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sotorasib Moderate
- Ranitidine + Trilaciclib Moderate
- Dofetilide + Ranitidine Minor
- Lonafarnib + Ranitidine Minor
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ranitidine with Sparsentan?
MediHelp rates the interaction as moderate. Ranitidine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan absorption may fall when gastric pH rises, which could weaken its antiproteinuric effect.
How serious is the interaction between Ranitidine and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor proteinuria and blood pressure response; consider separating dosing or choosing an alternative to the H2 blocker.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Infigratinib, Levoketoconazole, Sotorasib. The full list is on the Ranitidine page.
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