Drug interactions
Ranitidine + Sotorasib
Severity: Moderate
Ranitidine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility is pH-dependent, and acid-reducing drugs can reduce its exposure, so efficacy could be reduced; effects with H2 blockers are modest.
What this interaction means in plain words
Ranitidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranitidine belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Ranitidine raises gastric pH, reducing the pH-dependent dissolution and absorption of sotorasib.
What to do
Take sotorasib 4 hours before or 10 hours after the H2 blocker, or use a locally acting antacid instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranitidine
- Infigratinib + Ranitidine Moderate
- Levoketoconazole + Ranitidine Moderate
- Ranitidine + Sparsentan Moderate
- Ranitidine + Trilaciclib Moderate
- Dofetilide + Ranitidine Minor
- Lonafarnib + Ranitidine Minor
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ranitidine with Sotorasib?
MediHelp rates the interaction as moderate. Ranitidine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib solubility is pH-dependent, and acid-reducing drugs can reduce its exposure, so efficacy could be reduced; effects with H2 blockers are modest.
How serious is the interaction between Ranitidine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take sotorasib 4 hours before or 10 hours after the H2 blocker, or use a locally acting antacid instead.
What other medicines interact with Ranitidine?
MediHelp also lists interactions of Ranitidine with, for example, Infigratinib, Levoketoconazole, Sparsentan. The full list is on the Ranitidine page.
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