Drug interactions
Infliximab + Pexidartinib
Severity: Moderate
Infliximab and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and infliximab can also cause hepatotoxicity rarely. Using them together may increase the chance of liver injury.
What this interaction means in plain words
Infliximab and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin before and regularly during combined therapy. Stop pexidartinib or infliximab if significant liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Infliximab with Pexidartinib?
MediHelp rates the interaction as moderate. Infliximab and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and infliximab can also cause hepatotoxicity rarely. Using them together may increase the chance of liver injury.
How serious is the interaction between Infliximab and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin before and regularly during combined therapy. Stop pexidartinib or infliximab if significant liver injury develops.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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