Drug interactions
Insulin aspart + Sotagliflozin
Severity: Moderate
Insulin aspart and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers glucose via SGLT inhibition, so combining it with insulin raises hypoglycemia risk. Ketoacidosis risk is also a concern in insulin-treated patients.
What this interaction means in plain words
Insulin aspart and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT1/2 inhibition and insulin.
What to do
Consider lowering the insulin dose when starting sotagliflozin and monitor glucose closely. Monitor for ketoacidosis, including with normal glucose levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin aspart with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin aspart and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers glucose via SGLT inhibition, so combining it with insulin raises hypoglycemia risk. Ketoacidosis risk is also a concern in insulin-treated patients.
How serious is the interaction between Insulin aspart and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting sotagliflozin and monitor glucose closely. Monitor for ketoacidosis, including with normal glucose levels.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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