Drug interactions
Insulin degludec + Lanreotide
Severity: Moderate
Insulin degludec and Lanreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can cause either hypoglycemia or hyperglycemia. Insulin requirements in diabetic patients may change after starting or stopping it.
What this interaction means in plain words
Insulin degludec and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Lanreotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism alters pancreatic insulin and glucagon secretion, changing glucose balance.
What to do
Monitor glucose more frequently when starting, changing or stopping lanreotide. Adjust insulin degludec dose to the readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Insulin degludec with Lanreotide?
MediHelp rates the interaction as moderate. Insulin degludec and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can cause either hypoglycemia or hyperglycemia. Insulin requirements in diabetic patients may change after starting or stopping it.
How serious is the interaction between Insulin degludec and Lanreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently when starting, changing or stopping lanreotide. Adjust insulin degludec dose to the readings.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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