Drug interactions
Insulin degludec + Medroxyprogesterone
Severity: Minor
Insulin degludec and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone may impair glucose tolerance and reduce insulin effectiveness, occasionally requiring higher insulin doses. The effect is usually modest.
What this interaction means in plain words
Insulin degludec and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Progestins may induce peripheral insulin resistance, opposing insulin action.
What to do
Monitor blood glucose when starting or stopping medroxyprogesterone and adjust the insulin dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Insulin degludec with Medroxyprogesterone?
MediHelp rates the interaction as minor. Insulin degludec and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Medroxyprogesterone may impair glucose tolerance and reduce insulin effectiveness, occasionally requiring higher insulin doses. The effect is usually modest.
How serious is the interaction between Insulin degludec and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping medroxyprogesterone and adjust the insulin dose if control changes.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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