Drug interactions
Insulin degludec + Prochlorperazine
Severity: Moderate
Insulin degludec and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can raise blood glucose and may reduce the effect of insulin, leading to poorer glycemic control. The effect is usually modest and gradual.
What this interaction means in plain words
Insulin degludec and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazine-related impaired insulin secretion and reduced insulin sensitivity, producing hyperglycemia that opposes insulin.
What to do
Monitor blood glucose more frequently when starting or stopping prochlorperazine. Adjust insulin degludec dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Prochlorperazine?
MediHelp rates the interaction as moderate. Insulin degludec and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can raise blood glucose and may reduce the effect of insulin, leading to poorer glycemic control. The effect is usually modest and gradual.
How serious is the interaction between Insulin degludec and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping prochlorperazine. Adjust insulin degludec dose as needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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