Drug interactions
Insulin degludec + Progesterone
Severity: Minor
Insulin degludec and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens can reduce insulin sensitivity and worsen glycemic control. Natural progesterone has a minor effect, but insulin needs may change slightly.
What this interaction means in plain words
Insulin degludec and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through progestogen-related insulin resistance.
What to do
Monitor blood glucose when progesterone is started, changed or stopped, and adjust the insulin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Progesterone?
MediHelp rates the interaction as minor. Insulin degludec and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens can reduce insulin sensitivity and worsen glycemic control. Natural progesterone has a minor effect, but insulin needs may change slightly.
How serious is the interaction between Insulin degludec and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when progesterone is started, changed or stopped, and adjust the insulin dose if needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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