Drug interactions
Insulin degludec-insulin aspart + Nadolol
Severity: Moderate
Insulin degludec-insulin aspart and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol, a nonselective beta-blocker, can hide the warning signs of hypoglycemia and prolong recovery from insulin-induced low glucose. It may also impair glucose control in some patients.
What this interaction means in plain words
Insulin degludec-insulin aspart and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Nonselective beta blockade masks adrenergic symptoms and inhibits glycogenolysis and gluconeogenic recovery.
What to do
Monitor glucose more frequently and educate the patient about masked symptoms. Adjust insulin doses based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Nadolol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol, a nonselective beta-blocker, can hide the warning signs of hypoglycemia and prolong recovery from insulin-induced low glucose. It may also impair glucose control in some patients.
How serious is the interaction between Insulin degludec-insulin aspart and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently and educate the patient about masked symptoms. Adjust insulin doses based on readings.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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