Drug interactions
Insulin degludec-insulin aspart + Quetiapine
Severity: Moderate
Insulin degludec-insulin aspart and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may reduce the efficacy of insulin in patients with diabetes. Glycemic control may deteriorate over time.
What this interaction means in plain words
Insulin degludec-insulin aspart and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Quetiapine promotes insulin resistance and metabolic disturbance, opposing insulin action.
What to do
Monitor blood glucose and HbA1c regularly and increase insulin as needed when quetiapine is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Quetiapine?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may reduce the efficacy of insulin in patients with diabetes. Glycemic control may deteriorate over time.
How serious is the interaction between Insulin degludec-insulin aspart and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and increase insulin as needed when quetiapine is started.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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