Drug interactions
Insulin degludec-insulin aspart + Ritonavir
Severity: Moderate
Insulin degludec-insulin aspart and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir and other HIV protease inhibitors can cause insulin resistance and hyperglycemia, and may worsen existing diabetes. Insulin requirements may rise and glycemic control may deteriorate.
What this interaction means in plain words
Insulin degludec-insulin aspart and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake, opposing the glucose-lowering effect of insulin.
What to do
Monitor blood glucose regularly after starting or changing ritonavir and increase insulin doses as needed. Review the HIV regimen if control remains poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Ritonavir?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir and other HIV protease inhibitors can cause insulin resistance and hyperglycemia, and may worsen existing diabetes. Insulin requirements may rise and glycemic control may deteriorate.
How serious is the interaction between Insulin degludec-insulin aspart and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting or changing ritonavir and increase insulin doses as needed. Review the HIV regimen if control remains poor.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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