Drug interactions
Insulin degludec-insulin aspart + Thioridazine
Severity: Moderate
Insulin degludec-insulin aspart and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine, like other phenothiazines, can raise blood glucose and impair glycemic control. In a patient on insulin this may lead to higher glucose readings and a need for higher insulin doses.
What this interaction means in plain words
Insulin degludec-insulin aspart and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as phenothiazines can cause insulin resistance and reduce insulin secretion.
What to do
Monitor blood glucose more frequently when thioridazine is started, changed or stopped, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Thioridazine?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine, like other phenothiazines, can raise blood glucose and impair glycemic control. In a patient on insulin this may lead to higher glucose readings and a need for higher insulin doses.
How serious is the interaction between Insulin degludec-insulin aspart and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when thioridazine is started, changed or stopped, and adjust the insulin dose as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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