Drug interactions
Insulin degludec-insulin aspart + Tolazamide
Severity: Moderate
Insulin degludec-insulin aspart and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with insulin gives additive glucose lowering and a higher risk of hypoglycemia, which can be severe or prolonged.
What this interaction means in plain words
Insulin degludec-insulin aspart and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Sulfonylurea stimulates endogenous insulin secretion in addition to exogenous insulin, producing additive pharmacodynamic effects.
What to do
Reduce the dose of insulin or sulfonylurea when combining and monitor glucose closely. Educate patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Tolazamide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with insulin gives additive glucose lowering and a higher risk of hypoglycemia, which can be severe or prolonged.
How serious is the interaction between Insulin degludec-insulin aspart and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of insulin or sulfonylurea when combining and monitor glucose closely. Educate patient on hypoglycemia recognition.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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