Drug interactions
Insulin degludec-insulin aspart + Tolbutamide
Severity: Moderate
Insulin degludec-insulin aspart and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining tolbutamide with insulin gives additive glucose lowering and a higher risk of hypoglycemia, which can be severe or prolonged.
What this interaction means in plain words
Insulin degludec-insulin aspart and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Sulfonylurea stimulates endogenous insulin secretion in addition to exogenous insulin, producing additive pharmacodynamic effects.
What to do
Reduce the dose of insulin or tolbutamide when combining and monitor glucose closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-insulin aspart and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Tolbutamide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining tolbutamide with insulin gives additive glucose lowering and a higher risk of hypoglycemia, which can be severe or prolonged.
How serious is the interaction between Insulin degludec-insulin aspart and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of insulin or tolbutamide when combining and monitor glucose closely.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
