Drug interactions
Insulin degludec-liraglutide + Prochlorperazine
Severity: Minor
Insulin degludec-liraglutide and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine, a phenothiazine, may raise blood glucose and so reduce control in patients taking insulin degludec-liraglutide. The effect is usually modest with short-term antiemetic use but can matter with prolonged or high-dose use.
What this interaction means in plain words
Insulin degludec-liraglutide and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-liraglutide belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazines can reduce insulin sensitivity and secretion, giving a pharmacodynamic opposition to antidiabetic therapy.
What to do
Monitor blood glucose when prochlorperazine is used regularly or for long periods. Adjust the antidiabetic dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Prochlorperazine?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine, a phenothiazine, may raise blood glucose and so reduce control in patients taking insulin degludec-liraglutide. The effect is usually modest with short-term antiemetic use but can matter with prolonged or high-dose use.
How serious is the interaction between Insulin degludec-liraglutide and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when prochlorperazine is used regularly or for long periods. Adjust the antidiabetic dose if control worsens.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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