Drug interactions
Insulin detemir + Sotagliflozin
Severity: Moderate
Insulin detemir and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin used with insulin increases the risk of hypoglycemia, and the combination also carries a ketoacidosis risk if insulin is reduced too much.
What this interaction means in plain words
Insulin detemir and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Sotagliflozin inhibits SGLT1 and SGLT2, increasing urinary glucose excretion and reducing intestinal glucose absorption independent of insulin, which adds to insulin's effect.
What to do
Consider lowering the insulin dose when starting sotagliflozin and monitor glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin detemir with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin detemir and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin used with insulin increases the risk of hypoglycemia, and the combination also carries a ketoacidosis risk if insulin is reduced too much.
How serious is the interaction between Insulin detemir and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting sotagliflozin and monitor glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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