Drug interactions
Insulin glargine + Liraglutide
Severity: Moderate
Insulin glargine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with insulin glargine lowers glucose further and increases hypoglycemia risk, so insulin doses often need reduction.
What this interaction means in plain words
Insulin glargine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive effects of exogenous insulin and GLP-1 receptor agonism enhancing glucose-dependent insulin secretion and suppressing glucagon.
What to do
Monitor glucose when starting liraglutide and consider reducing the insulin dose to prevent hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin glargine with Liraglutide?
MediHelp rates the interaction as moderate. Insulin glargine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with insulin glargine lowers glucose further and increases hypoglycemia risk, so insulin doses often need reduction.
How serious is the interaction between Insulin glargine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting liraglutide and consider reducing the insulin dose to prevent hypoglycemia.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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