Drug interactions
Insulin glargine + Tipranavir
Severity: Moderate
Insulin glargine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of insulin glargine. Glycemic control can deteriorate after the protease inhibitor is started.
What this interaction means in plain words
Insulin glargine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair peripheral glucose uptake and insulin sensitivity, antagonizing insulin action.
What to do
Monitor blood glucose and HbA1c after starting tipranavir. Titrate the insulin glargine dose upward as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Insulin glargine with Tipranavir?
MediHelp rates the interaction as moderate. Insulin glargine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of insulin glargine. Glycemic control can deteriorate after the protease inhibitor is started.
How serious is the interaction between Insulin glargine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting tipranavir. Titrate the insulin glargine dose upward as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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