Drug interactions
Insulin glulisine + Lanreotide
Severity: Moderate
Insulin glulisine and Lanreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide suppresses insulin, glucagon and growth hormone secretion, so glucose control can shift in either direction in patients using insulin. Both hypoglycemia and hyperglycemia have been reported with somatostatin analogs.
What this interaction means in plain words
Insulin glulisine and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Lanreotide belongs to Endocrine.
Why it happens
Pharmacodynamic: somatostatin analog inhibits endogenous insulin and counter-regulatory hormone (glucagon, GH) release, altering insulin requirements.
What to do
Monitor blood glucose more frequently when starting, changing or stopping lanreotide. Adjust the insulin glulisine dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Insulin glulisine with Lanreotide?
MediHelp rates the interaction as moderate. Insulin glulisine and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanreotide suppresses insulin, glucagon and growth hormone secretion, so glucose control can shift in either direction in patients using insulin. Both hypoglycemia and hyperglycemia have been reported with somatostatin analogs.
How serious is the interaction between Insulin glulisine and Lanreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, changing or stopping lanreotide. Adjust the insulin glulisine dose according to readings.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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