Drug interactions
Insulin lispro + Sotagliflozin
Severity: Moderate
Insulin lispro and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin, an SGLT1/SGLT2 inhibitor, lowers glucose independently of insulin. With insulin lispro it increases hypoglycemia risk, and ketoacidosis risk is a concern if insulin is cut too aggressively.
What this interaction means in plain words
Insulin lispro and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
SGLT inhibition adds insulin-independent glucose lowering to exogenous insulin.
What to do
Consider reducing the insulin lispro dose when starting sotagliflozin and monitor blood glucose. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin lispro with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin lispro and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin, an SGLT1/SGLT2 inhibitor, lowers glucose independently of insulin. With insulin lispro it increases hypoglycemia risk, and ketoacidosis risk is a concern if insulin is cut too aggressively.
How serious is the interaction between Insulin lispro and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin lispro dose when starting sotagliflozin and monitor blood glucose. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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