Drug interactions
Insulin neutral human-insulin isophane protamine human + Sotagliflozin
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding sotagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which can be masked when insulin doses are cut too much.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering: SGLT inhibition causes urinary glucose loss independent of insulin action.
What to do
Consider reducing the insulin dose when starting sotagliflozin and monitor glucose. Avoid excessive insulin reduction and check ketones if the patient is unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding sotagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which can be masked when insulin doses are cut too much.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting sotagliflozin and monitor glucose. Avoid excessive insulin reduction and check ketones if the patient is unwell.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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