Drug interactions
Interferon beta 1a + Lomustine
Severity: Moderate
Interferon beta 1a and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes delayed and cumulative myelosuppression, and interferon beta can also lower blood counts. Together the risk of severe cytopenias and infection or bleeding may be higher.
What this interaction means in plain words
Interferon beta 1a and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Interferon beta 1a belongs to Central Nervous System; Lomustine belongs to Oncology.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts frequently, including in the weeks after lomustine dosing, and reduce or hold either drug for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Interferon beta 1a
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Interferon beta 1a with Lomustine?
MediHelp rates the interaction as moderate. Interferon beta 1a and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes delayed and cumulative myelosuppression, and interferon beta can also lower blood counts. Together the risk of severe cytopenias and infection or bleeding may be higher.
How serious is the interaction between Interferon beta 1a and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, including in the weeks after lomustine dosing, and reduce or hold either drug for significant cytopenias.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Hydroxycarbamide. The full list is on the Interferon beta 1a page.
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