Drug interactions
Ipratropium + Promethazine
Severity: Minor
Ipratropium and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can intensify dry mouth, blurred vision, urinary retention, constipation and tachycardia. Systemic exposure to inhaled ipratropium is low, so the effect is usually modest, but it may be more noticeable in older patients or those with glaucoma or prostatic hypertrophy.
What this interaction means in plain words
Ipratropium and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium belongs to Respiratory; Promethazine belongs to Respiratory.
Why it happens
Additive anticholinergic (muscarinic receptor blockade) effects.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation and blurred vision, especially in elderly patients or those with narrow-angle glaucoma. Reduce or stop one agent if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Promethazine?
MediHelp rates the interaction as minor. Ipratropium and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have antimuscarinic activity, so combined use can intensify dry mouth, blurred vision, urinary retention, constipation and tachycardia. Systemic exposure to inhaled ipratropium is low, so the effect is usually modest, but it may be more noticeable in older patients or those with glaucoma or prostatic hypertrophy.
How serious is the interaction between Ipratropium and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and blurred vision, especially in elderly patients or those with narrow-angle glaucoma. Reduce or stop one agent if symptoms develop.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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