Drug interactions
Ipratropium-salbutamol + Lopinavir
Severity: Moderate
Ipratropium-salbutamol and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT interval, and salbutamol can cause tachycardia and hypokalemia. The combination may modestly raise arrhythmia risk, particularly with high-dose salbutamol or electrolyte disturbance.
What this interaction means in plain words
Ipratropium-salbutamol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a further risk factor.
What to do
Monitor ECG and potassium in patients with risk factors, and avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Lopinavir?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT interval, and salbutamol can cause tachycardia and hypokalemia. The combination may modestly raise arrhythmia risk, particularly with high-dose salbutamol or electrolyte disturbance.
How serious is the interaction between Ipratropium-salbutamol and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with risk factors, and avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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