Drug interactions
Ipratropium-salbutamol + Ranolazine
Severity: Moderate
Ipratropium-salbutamol and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine prolongs the QT interval in a dose-related way and salbutamol can add to this, particularly if hypokalemia develops. The risk is greatest with high or repeated salbutamol doses or in patients with other proarrhythmic factors.
What this interaction means in plain words
Ipratropium-salbutamol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Keep salbutamol at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ipratropium-salbutamol and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Ranolazine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine prolongs the QT interval in a dose-related way and salbutamol can add to this, particularly if hypokalemia develops. The risk is greatest with high or repeated salbutamol doses or in patients with other proarrhythmic factors.
How serious is the interaction between Ipratropium-salbutamol and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Keep salbutamol at the lowest effective dose.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
