Drug interactions
Ipratropium-salbutamol + Risperidone
Severity: Moderate
Ipratropium-salbutamol and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can prolong the QT interval and salbutamol may add a small additional effect, particularly if hypokalemia occurs. Salbutamol can also cause tachycardia and hypotension through vasodilation, which may be more pronounced with risperidone's alpha-blocking activity. Systemic anticholinergic effects from inhaled ipratropium are minimal.
What this interaction means in plain words
Ipratropium-salbutamol and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and overlapping cardiovascular effects, with beta-agonist-induced hypokalemia contributing.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors or on high-dose salbutamol. Check potassium if repeated beta-agonist dosing is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Risperidone?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can prolong the QT interval and salbutamol may add a small additional effect, particularly if hypokalemia occurs. Salbutamol can also cause tachycardia and hypotension through vasodilation, which may be more pronounced with risperidone's alpha-blocking activity. Systemic anticholinergic effects from inhaled ipratropium are minimal.
How serious is the interaction between Ipratropium-salbutamol and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors or on high-dose salbutamol. Check potassium if repeated beta-agonist dosing is needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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